Annova Plus

500/20 mg

500/20 mg

📌 Generic Composition

• Naproxen sodium – a NSAID (non‑steroidal anti‑inflammatory drug)

• Esomeprazole magnesium – a proton pump inhibitor (PPI)

This combination pairs enteric‑coated naproxen (for pain/inflammation) with an immediate-release layer of esomeprazole (to reduce stomach acid), protecting against NSAID-induced ulcers. 

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💊 Dosage Forms & Strengths

Available as delayed-release, capsule-shaped, film-coated oral tablets with two strengths:

• 375 mg naproxen / 20 mg esomeprazole

• 500 mg naproxen / 20 mg esomeprazole

Tablets are biconvex, off-white to yellow, printed with identification codes (“R 289” for 375/20; “R 701” for 500/20). 

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🧑⚕️ Indications & Dosage

Adults (≥18 years)

• One tablet twice daily, at least 30 minutes before meals:

  • 375 mg/20 mg or

  • 500 mg/20 mg naproxen/esomeprazole 

Used for:

• Rheumatoid arthritis

• Osteoarthritis

• Ankylosing spondylitis

• Patients needing NSAID therapy with ulcer risk

Adolescents (12 years & older) with Juvenile Idiopathic Arthritis

• Weight 38–<50 kg: 375 mg/20 mg twice daily

• Weight ≥50 kg: either 375/20 or 500/20 twice daily 

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⚠️ Administration Notes

• Swallow whole with water at least 30 minutes before meals

• Do not chew, crush, or split the tablet 

• If a dose is missed, take ASAP unless the next dose is near — do not double up 

• Antacids may be used concurrently 

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🧩 Product Description

A combination therapy branded as Vimovo in some markets, consisting of an enteric‑coated naproxen core surrounded by an immediate-release esomeprazole layer. This design delays naproxen absorption (reducing acute pain use) while promptly lowering gastric acid to protect the stomach.

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📊 Summary Table

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✅ Final Takeaway

Annova Plus is a prescription-only, delayed-release tablet combining naproxen sodium and esomeprazole magnesium. It’s designed for twice-daily use (either 375/20 or 500/20 mg) in adults and appropriate adolescents to treat arthritis symptoms and reduce the risk of NSAID-related gastric ulcers. It must be swallowed whole, 30 minutes before meals, as part of a carefully managed treatment plan under physician guidance.