Criston 2 Injection

• Generic Name: Vincristine Sulfate

• Strength: 2 mg/2 ml (1 mg/ml)

• Dosage Form: Intravenous (IV) injection

Product Description:

Criston IV Injection contains Vincristine Sulfate, a vinca alkaloid chemotherapeutic agent derived from the periwinkle plant (Catharanthus roseus). It works by inhibiting microtubule formation in mitotic spindle, thereby arresting cell division at metaphase. It is primarily used in the treatment of various cancers including:

• Acute lymphoblastic leukemia (ALL)

• Hodgkin’s and non-Hodgkin’s lymphomas

• Neuroblastoma

• Rhabdomyosarcoma

• Wilms’ tumor

Dosage:

• Route: Intravenous only; never intrathecal due to fatal neurotoxicity.

• Adult Dosage: Typically 1.4 mg/m² once weekly (maximum 2 mg/week)

• Pediatric Dosage: Based on body surface area or weight; individualized per protocol.