Flexibac

100 ml

• Generic Name: Baclofen

• Strength: 100 mg per 100 ml oral solution (i.e., 5 mg per 5 ml)

• Formulation: Oral solution available in 100 ml bottles, usually orange‑flavoured

• Manufacturer: Beacon Pharmaceuticals Ltd. (Bangladesh) 

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🧠 Indications

Flexibac syrup is prescribed to relieve muscle spasticity and associated symptoms in conditions such as:

• Multiple sclerosis (spasticity, flexor spasms, clonus, rigidity)

• Rheumatic muscle disorders

• Spinal cord injury or disease

• Cerebrovascular accidents (stroke), neoplastic or degenerative brain disease

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⚙️ Mechanism of Action

• Stimulates GABA$_B$ receptors in the spinal cord, inhibiting both mono‑ and polysynaptic reflexes

• Suppresses release of excitatory neurotransmitters (glutamate, aspartate)

• May have central antinociceptive (pain‑relief) effects

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🧭 Dosage & Administration

• Adults & Children ≥10 years: Start with 5 mg (5 ml) three times daily with food. Titrate up gently; usual maximum 80–100 mg/day

• Children <10 years: Begin with 2.5 mg (2.5 ml) four times daily. Maintenance dosing varies by age group:

  • 12 mo–2 yr: 10–20 mg/day

  • 2–6 yr: 20–30 mg/day

  • 6–10 yr: 30–60 mg/day 

• Dosage adjustments required for elderly or patients with renal impairment

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⚠️ Contraindications & Precautions

• Do not use in cases of hypersensitivity to baclofen

• Use cautiously if the patient has:

  • Peptic ulcer disease

  • Epilepsy

  • Psychiatric conditions

  • Cerebrovascular or cardiopulmonary disorders

  • Hepatic or renal impairment

  • Avoid abrupt discontinuation—withdrawal can occur

• Pregnant (Category B3) and nursing mothers: only if benefits outweigh risks 

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⚕️ Interactions

• Additive CNS depression with alcohol, opioids, other sedatives; higher risk of respiratory depression

• May enhance hypotensive effects of antihypertensives

• Interactions with TCAs lead to increased muscle relaxation

• Levodopa/carbidopa combination may cause confusion, hallucinations

• Caution with MAO inhibitors, neuromuscular blockers 

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🚨 Side Effects

Common (≥10%): drowsiness, sedation, dizziness, weakness, fatigue
Less frequent: headache, insomnia, euphoria, confusion, hallucinations, nausea, constipation, urinary changes, hypotension, respiratory depression, seizures, coordination problems, visual disturbances, rash, weight gain, etc.

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🌡️ Overdose & Storage

• Overdose: Gastric lavage may be needed; respiratory and cardiac support critical

• Storage: Keep below 30 °C, protect from light and moisture. Store out of reach of children

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📋 Summary Table