Ifomes Injection

Generic Name: Mesna
Strength: 400 mg/4 ml (i.e., 100 mg/ml)
Dosage Form: Intravenous (IV) Injection

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Product Description:

Ifomes contains Mesna, a synthetic sulfhydryl compound used as a uroprotective agent. It is primarily indicated to reduce the risk of hemorrhagic cystitis caused by oxazaphosphorine chemotherapy drugs such as ifosfamide and cyclophosphamide.

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Dosage:

The dosage of Mesna (Ifomes) depends on the dose of the accompanying chemotherapy (usually ifosfamide) and may vary according to treatment protocol. A common regimen includes:

• IV Mesna (Ifomes):

  • Administered at 20% of the ifosfamide dose (on a mg-to-mg basis), typically at the following schedule:

    • 15 minutes before ifosfamide

    • Then 4 hours and 8 hours after ifosfamide administration.

Example:

For ifosfamide 1,000 mg/m², mesna (Ifomes) dose = 200 mg/m² IV at each time point (total of 600 mg/m²/day).

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Note:

• Ensure adequate hydration and urinary output during mesna therapy.

• Mesna has a short half-life, so timely administration is critical.

• It can also be administered orally in some regimens, following the IV dose.