Mezest

40 mg

160 mg

Generic Name: Megestrol Acetate
Strengths Available: 40 mg, 160 mg

Product Description:

Mezest Tablet contains Megestrol Acetate, a synthetic derivative of the hormone progesterone. It is classified as a progestational agent.

Indications:

• Appetite Stimulation: Used in patients experiencing anorexia, cachexia, or unexplained significant weight loss, particularly in cancer and AIDS patients.

• Hormone Therapy in Cancer: Indicated for the treatment of hormone-responsive cancers such as breast cancer and endometrial carcinoma.

Mechanism of Action:

Megestrol Acetate exerts progestational effects and has anti-gonadotropic properties, leading to the inhibition of pituitary gonadotropin secretion. It also has appetite-stimulating and anti-inflammatory effects, although the exact mechanism of appetite stimulation is not fully understood.

Dosage Forms and Strengths:

• Mezest 40 mg Tablet

• Mezest 160 mg Tablet

Common Side Effects:

• Weight gain

• Nausea

• Edema (fluid retention)

• Increased appetite

• Thromboembolic events (rare)

Precautions:

• Use with caution in patients with a history of thromboembolic disease.

• Should be avoided during pregnancy unless clearly needed.

• Monitor for adrenal suppression in long-term use.