Mezest

40mg

160mg

Product Name: Mezest®
Active Ingredient: Mesalamine (also known as Mesalazine)
Available Strengths: 40 mg, 160 mg
Pharmaceutical Form: Delayed-release tablets / enteric-coated tablets (formulation may vary by manufacturer)

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Description:

Mezest® contains mesalamine, an anti-inflammatory drug used primarily in the treatment of inflammatory bowel diseases. Mesalamine works locally in the colon to reduce inflammation and is structurally related to salicylates.

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Indications:

• Ulcerative colitis (UC):

  • Treatment of mild to moderate active UC.

  • Maintenance of remission in UC.

• Other inflammatory bowel conditions as directed by a physician.

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Mechanism of Action:

Mesalamine acts locally on the colonic mucosa to inhibit the production of pro-inflammatory mediators, such as prostaglandins and leukotrienes, through the inhibition of cyclooxygenase and lipoxygenase pathways.

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Dosage and Administration:

Dosage depends on the severity of the disease and physician recommendation.
Typical maintenance doses:

• 40 mg tablets: Used in pediatric dosing or mild cases as directed.

• 160 mg tablets: For higher dosing requirements, administered as per clinical judgment.

Tablets should be swallowed whole, not crushed or chewed, to ensure proper drug release.

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Contraindications:

• Hypersensitivity to mesalamine, salicylates, or any component of the formulation.

• Severe liver or kidney impairment.

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Precautions:

• Renal and hepatic function monitoring recommended.

• Caution in patients with a history of allergic reactions to sulfasalazine or aspirin-like drugs.

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Adverse Effects:

• Common: Headache, nausea, abdominal pain, diarrhea.

• Less common: Rash, hypersensitivity reactions, pancreatitis, nephrotoxicity (rare).

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Storage:

Store below 30°C. Protect from moisture and light.