Pradox Injection

Generic Name: Dabigatran Etexilate (commonly, "Pradox" refers to Dabigatran in some markets; please confirm your local product)
Form: Injection (Note: Dabigatran is typically available in oral form; injectable formulations may refer to specific clinical or research-use preparations or related agents like idarucizumab for reversal)
Strength: Please specify, as strengths may vary.

---

Product Description:

Pradox Injection is an anticoagulant medication used in the management of thromboembolic disorders. Dabigatran is a direct thrombin inhibitor, preventing the formation of blood clots by inhibiting the activity of thrombin (Factor IIa).

Indications:

• Prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation.

• Treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE).

• Reversal of dabigatran-induced anticoagulation (when referring to idarucizumab, e.g., Praxbind).

---

Mechanism of Action:

Dabigatran inhibits both free and clot-bound thrombin, reducing the conversion of fibrinogen to fibrin and preventing thrombus formation.

---

Common Side Effects:

• Bleeding complications

• Gastrointestinal discomfort (if orally administered)

• Injection site reactions (if applicable)

• Headache

• Nausea

---

Contraindications:

• Active bleeding disorders

• Severe renal impairment (unless adjusted)

• Known hypersensitivity to dabigatran or formulation components