Safoxol Capsule

75 mg

Generic Name

• Ambroxol hydrochloride 

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💊 Indications

Safoxol is used to treat various respiratory tract conditions characterized by thick, sticky mucus, including:

• Productive cough

• Acute or chronic bronchitis

• Laryngitis, pharyngitis, sinusitis, rhinitis with viscid mucus

• Asthmatic or bronchial bronchitis

• Bronchiectasis

• Chronic pneumonia 

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⚙️ Mechanism of Action & Pharmacology

• Ambroxol is a metabolite of bromhexine with powerful mucokinetic and secretolytic actions:

  • Thins and liquefies mucus, improving transport and expectoration by depolymerizing mucoproteins and mucopolysaccharides 

  • Stimulates serous bronchial glands to increase mucus production 

  • Enhances pulmonary surfactant production by alveolar cells, reducing surface tension

  • Demonstrates anti‑inflammatory and antioxidant effects, including inhibition of cytokine and arachidonic acid metabolite release

  • Beneficial in COPD by improving airway patency 

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📏 Dosage & Administration

• Adults (≥ 12 years): 1 sustained‑release capsule (75 mg) once daily, preferably with food.

• Pediatric formulations are available (drops, syrup); capsules are for those 12 and older.

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⚠️ Warnings & Precautions

• Use with caution in:

  • Kidney or liver impairment

  • Gastro‑duodenal ulcers

  • Convulsive disorders

• Contraindicated in patients allergic to ambroxol or bromhexine 

• Avoid using with antitussives like codeine, since these may hinder mucus clearance

• Not recommended during pregnancy and breastfeeding unless prescribed by a physician.

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🧾 Adverse Effects

Common side effects include gastrointestinal upset such as nausea, vomiting, dyspepsia, and occasionally allergic reactions (rash, urticaria, rare angioedema)

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✅ Summary

Safoxol 75 mg capsules are a once‑daily sustained‑release ambroxol formulation designed to:

• Thin and mobilize mucus

• Facilitate productive coughing

• Provide anti‑inflammatory and surfactant‑boosting effects