Trexonate Injection

• Generic Name: Methotrexate

• Strength: 50 mg/2 ml (i.e., 25 mg/ml)

• Dosage Form: Intravenous (IV) Injection or Infusion

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Product Description:

Trexonate contains Methotrexate, an antimetabolite and antifolate agent used in the treatment of various cancers (like leukemia, lymphoma, breast cancer), autoimmune diseases (like rheumatoid arthritis), and ectopic pregnancy.

Methotrexate works by inhibiting dihydrofolate reductase, an enzyme involved in DNA synthesis, leading to suppression of rapidly dividing cells.

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Common Dosage (for reference only; individual dosage must be prescribed by a physician):

• Cancer treatment:

  • Adults: 10–25 mg/m² IV once weekly, or as per protocol

  • High-dose regimens: Up to several grams/m² with leucovorin rescue

• Rheumatoid arthritis / psoriasis (less common IV route): 7.5–25 mg/week

• Ectopic pregnancy: Single-dose or multi-dose protocol (e.g., 50 mg/m² IM or IV)