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cellular senescence

Senescent Cells and Kidney Disease: Is Cellular Aging the New Frontier?

Cellular senescence — the accumulation of damaged, permanently arrested cells that drive inflammation and fibrosis — is emerging as a key mechanism in CKD progression. Early clinical trials and preclinical data on senolytic compounds, including quercetin, fisetin, and dasatinib, suggest that targeting these cells may one day become a standard part of kidney disease management.